Impact of S - Adenosylmethionine Decarboxylase 1 in Pulmonary Vascular Remodeling Running title :
نویسندگان
چکیده
Friederike Christine Weisel, PhD; Christina Kloepping, DVM; Alexandra Pichl, PhD; Akylbek Sydykov, MD, PhD; Baktybek Kojonazarov, MD, PhD; Jochen Wilhelm, PhD; Markus Roth, PhD; Karen Marie Ridge, PhD; Kazuei Igarashi, PhD; Kazuhiro Nishimura, PhD; Wolfgang Maison, PhD; Claudia Wackendorff ; Walter Klepetko, MD; Peter Jaksch, MD; Hossein Ardeschir Ghofrani, MD; Friedrich Grimminger, MD, PhD; Werner Seeger, MD; Ralph Theo Schermuly, PhD; Norbert Weissmann, PhD; Grazyna Kwapiszewska, PhD
منابع مشابه
Impact of S-adenosylmethionine decarboxylase 1 on pulmonary vascular remodeling.
BACKGROUND Pulmonary hypertension (PH) is a life-threatening disease characterized by vascular remodeling and increased pulmonary vascular resistance. Chronic alveolar hypoxia in animals is often used to decipher pathways being regulated in PH. Here, we aimed to investigate whether chronic hypoxia-induced PH in mice can be reversed by reoxygenation and whether possible regression can be used to...
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Abbreviations: ACL5, ACAULIS5; ATHB8, ARABIDOPSIS THALIANA HOMEOBOX8; bHLH, basic helix-loop-helix; 2,4-D IOE, isooctyl ester of 2,4-dichlorophenoxyacetic acid; EMS, ethyl methanesulfonate; GUS, β-glucuronidase; LHW, LONESOME HIGHWAY; mORF, main open-reading frame; MP, MONOPTEROS; PAO, POLYAMINE OXIDASE; SAC, SUPPRESSOR-OF-ACL5; SACL, SAC-LIKE; SAMDC, S-adenosylmethionine decarboxylase; TMO5, T...
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Effect of thoracic epidural blockade on hypoxia-induced pulmonary arterial hypertension in rats
Objective(s): The present study was aimed to investigate the influence of thoracic epidural blockade on hypoxia-induced pulmonary hypertension in rats. Materials and Methods: Forty eight Wistar rats were randomly divided into 4 equal groups, named normoxia hypoxia hypoxia/ ropivacaine and hypoxia/saline. Animals were placed in a hypoxia chamber and instrumented with epidural catheters at the t...
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1. S-Adenosyl-L-methionine decarboxylase (S-adenosyl-L-methionine carboxy-lyase, EC 4.1.1.50) was purified more than 1100-fold from extracts of Saccharomyces cerevisiae by affinity chromatography on columns of Sepharose containing covalently bound methylglyoxal bis(guanylhydrazone) (1,1'[(methylethanediylidene)dinitrilo]diguanidine) [Pegg, (1974) Biochem J. 141, 581-583]. The final preparation ...
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